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KMID : 0381219730050120503
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Journal of RIMSK
1973 Volume.5 No. 12 p.503 ~ p.512
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The Significance of Feed Back Mechanism on the Regulation of Sexual Function and Relationship Between Cerebral Limbic and Hypothalamic Pituitary Gonadal System
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Abstract
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The feed back actions (negative and positive) are most fundamental factor in the regulation of hormonal secretion for the purpose of maintaining the homeostasis. In the past, the feed back mechanism of steroid hormones had been proved on the hypothalamus or pituitary, but until recently it has not been clarified on the brain (especially cerebral limbic system). There are long and short loop in the feed back actions.
I) The classification of feed back action.
1) Long (external) loop feed back,
steroidhormones act on the hypothalamus or pituitary. 2) Short (internal) loop .feed back.
a) Short feed back action in narrow sense;
pituitary hormones act mainly on the hypothalamus.
b) Auto feed back action;
pituitary hormone (FSH or ACTH) acts on the anterior pituitary.
c) Ultra short feed back action;
hypothalamic hormone (FSH-RF or TSH-RF) acts on the hypothalamus.
In the physiologic condition, the long feed back action plays a great role in the regulation of hormonal function, whereas short loop feed back action may act on the hypothalamus or pituitary as an autonomic safe valve to prevent the unbalanced pituitary hormone secretion in abnormal emergent condition. But the ultra short feed back action may be suggested as a subsidiary one.
I ) The limbic and hypothalamic-pituitary system.
By various experiments on animal cerebral limbic system (suggested as a center of autonomic nervous system), They point increasingly to the controlling role of the limbic system in the regulation of gonadotropin release. Among the limbic system, the representative regions related to sexual function are amygdala, hippocampus and midbrain reticular formation.
The results of electrical stimulation provide evidence that the amygdala exerts a stimulatory effect
on the release of LH and FSH, but the hippocampus exerts an inhibitory influence. On the other hand, in the midbrain reticular formation closely related to hypothalamus, its hyperfunction leads to activate the hypothalamic-pituitary functions, whereas its hypofunction decreases them.
By EEG patterns of brain, they provide evidence that sex steroids are capable of altering thresholds in the brain and thus play a basic role in the aspects of central nervous system physiology other than those exclusively concerned sexual function. this means that sex steroids act on the amygdala and hippocamp by negative or positive feed back and regulate the hypothalamo-pituitary hormones.
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